Monday, July 25, 2011
Grand Ballroom, 5th fl (Sheraton New Orleans)
Industrial and biopharmaceutical organizations must reduce timelines and manage ever-shrinking resources to successfully meet deadlines for commercial product launches. At the same time, today’s organizations are not just developing products using one expression platform but many, for example, bacteria, yeast, CHO, and fungi. It is beneficial to have a controlled scale-up/scale-down tool that is flexible enough to be used to develop a variety of expression platforms. Both microbial and mammalian scientists are using the Micro-24 Microbioreactor in cell line selection activities and also in process development. The Micro-24 is a 24 well system with individual pH, DO, and temperature control which allows users to maximize the likelihood of obtaining a “winning” cell line prior to commercialization. Data will be presented showing the Micro-24 being utilized successfully in cell line selection activities (ranking clones) and process optimization (parameter optimization) activities and its scalability to larger bioreactors. The data will show how small-scale bioreactors such as the Micro-24 Microbioreactor are changing the way cell line selection and process development is being conducted to maximize the likelihood of success by running in a controlled environment earlier in the development process.