Wednesday, July 27, 2011: 10:30 AM
Bayside A, 4th fl (Sheraton New Orleans)
Thiamin pyrophosphate plays a key role in the stabilization of the acyl carbanion synthon in carbohydrate and amino acid metabolism and is an essential cofactor in all living systems. The biosynthesis of the thiamin pyrimidine and thiazole is complex and different from any of the characterized chemical or biochemical routes to these heterocycles. In bacteria lacking a thiamin uptake system, the biosynthetic enzymes are potential targets for antibiotic development. This presentation will describe recent progress with the functional characterization of the TenA and TenI genes involved in thiamin biosynthesis.
See more of: Toward correct assignments of enzyme function in genomic databases
See more of: Invited Oral Papers
See more of: Invited Oral Papers