Development of a chemically defined batch and feed medium for E. coli fermentations producing therapeutic proteins
Mark Berge, Hedieh Barkhordarian and Xiaoming (Jerry) Yang, Cell Science and Technology, Amgen Inc., Thousand Oaks, CA

Fed-batch process of rapamycin fermentation with DCO₂ on-line measurement
Yinliang Chen, Jeffrey Krol, Weimin Huang, Richard Mirro and Vik Gossain, R & D Lab, New Brunswick Scientific, Edison, NJ

Break

Carbohydrate source optimization for a mammalian production cell culture
Carmen Chin¹, Yuval Shimon¹, Teng Liu¹, Veronica Hernandez-Rodriguez¹, Jin Wang¹, Peter Kramer¹ and Volker Moehrle², (1)Bayer, San Francisco, CA, (2)Bayer Technology Services, Leverkusen, Germany

Can lactate actually be beneficial to CHO cell culture processes?
Jincai Li¹, Nattu Vijayasankaran¹, Terry Hudson¹, Ashraf Amanullah¹ and Chun Loong Wong², (1)Genentech, South San Francisco, CA, (2)Bioprocessing Technology Institute, Sisngapore, Singapore

Semi-synthetic antimalarial from yeast: Crucial roles for improved enzymes and fermentation processes in the high-level production of artemisinic acid
Kirsten Benjamin, Amyris Biotechnologies Inc., Emeryville, CA

Implementation of harvested cell culture fluid (HCCF) air sparging to prevent antibody disulfide bond reduction
Melissa Mun, Genentech, South San Francisco, CA