S91: Production of virus-like particles (VLPs) in a fungal production platform

Tuesday, August 3, 2010: 9:00 AM
Seacliff AB (Hyatt Regency San Francisco)
Debbie Higgins, Edward B. Cambareri, Silke Allgaier, Yuliya Brudnaya and W. Dorsey Stuart, Neugenesis Corporation, Burlingame, CA
The world-wide requirement for new vaccine production platforms is expanding, and the ability to produce vaccines rapidly and cost effectively is key.  A Neurospora crassa fungal production platform is being developed to rapidly produce large amounts of immunogenic and protective VLPs and subunit vaccines.

The Neugenesis fungal production platform for vaccines uses optimized expression vectors and fungal host strains that can be quickly adapted to produce vaccines in weeks, rather than months.  Comparison to production methods on a yield per volume basis shows the fungal production platform can be significantly more efficient than current methods. 

Production facilities utilizing the fungal platform are simple and can be multifunctional with the ability to produce a variety of vaccines and other protein biologics.  This versatility further reduces manufacturing costs, making access to these manufactured biologics possible for larger populations, particularly in developing countries.  The combined flexibility, rapid high yield production capacity and animal-free system provide a significant enhancement over current production methods.  The potential of a fungal platform for production of vaccine antigens is broad and deep and the subsequent positive impact on public health considerable.