P14: A Modular Integrative Framework Solution for New Enzymes and their Production in Industrial Biotechnology

Monday, August 2, 2010
Pacific Concourse (Hyatt Regency San Francisco)
Sebastien Ribrioux1, Nadim Jessani2, Jon Tupy2, Thomas Hartsch1, Ludwig Macko1 and Hans-Peter Fischer1, (1)Genedata, Basel, Switzerland, (2)Genedata, San Francisco, CA
Industrial Biotech R & D is highly diverse and covers activities ranging from screening of environmental genomic samples, identification and characterization of new enzymes, and protein engineering, to full implementation of production systems including up-scaling and downstream processing optimization.
Genedata, a leading provider of life science computational solutions, supports the industrial biotechnology R & D process with interactive tools that give researchers access to comprehensive, coherent, research-critical information. Here we outline how

Genedata eliminates the barriers between data acquisition, data analysis, decision making and IP-protection to streamline the R & D process. The modular system facilitates identification of new potential enzymes by providing storage and data mining of new sequence information from metagenomes or organisms. It comprehensively manages early discovery data prior to hand-over to development, including functional characterization results, and registration of biological materials such as plasmids, expression systems and purified samples. Available genome information on production strains or previous expression systems is also integrated, which facilitates the choice of best production system and process optimization. In combination with transcriptomics, proteomics and metabolomics data, it forms the basis for an integrated in-depth understanding of cellular metabolism and the generation of production models. Finally, the platform offers seamless integration of tools to investigate and track the current patent situation, critical for decision support in product management.