Monday, August 2, 2010
Pacific Concourse (Hyatt Regency San Francisco)
As part as our continuous research on the biological and chemical diversity of marine actinomycetes, we have recognized a variety of new actinomycete taxa occur in the ocean. One of these new marine-derived actinomycetes related to the genus Streptomyces, that is proving to be of significant chemical interest, has been tentatively designated MAR4. The chemical investigation of a cultured MAR4 strain, CNQ-509, that was isolated from a marine sediment sample, led to the isolation of two new naphthoquinone derivatives (1 and 2), together with a previously reported debromomarinone. The structures of these compounds were consisted of two separated substructures, a naphthoquinone and a terpenoid. The analysis of spectral data and chemical modifications provided the full structures of compounds 1 and 2.