Wednesday, July 29, 2009 - 9:00 AM
S110

Bioengineering of fuel-latent plastics and their conversion to biodiesel

Jon Ness1, Richard Gross2, Jeremy Minshull1, and Sridhar Govindarajan1. (1) DNA2.0 Inc., 1430 Suite E, O’Brien Drive, Menlo Park, CA 94025, (2) Polytechnic University, Brooklyn, NY 11201

We present our work on engineering cutinases for degradation of plastics. This step is a part of three-step process for developing fuel-latent plastics and their conversion to biodiesel. DNA2.0’s ProteinGPS™ technology systematically searches the sequence space using state-of-the-art gene synthesis technologies and machine learning algorithms. The need for high-throughput screening is eliminated in this approach and instead we measure protein properties directly under the final “commercial use” assay. We were able to achieve improvements by testing only 102 variants over two rounds.

 


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