Thursday, July 30, 2009 - 8:30 AM
S138

Metabolic Engineering of E. coli for the production of fatty acid like chemicals from biorenewables

Ka-Yiu San, Bioengineering, Rice University, 6100 Main Street, BioE Dept, MS 142, Houston, TX 77005

Our group recently is interested in the metabolic engineering of Escherichia coli to produce fatty acid like chemicals. This focus is one of the major research thrusts of a recently established NSF Engineering Research Center “Center for Biorenewable Chemicals” (CBiRC). The long term goal of CBiRC is to develop the fundamental knowledge and technology needed to provide a foundation for industrial chemical production to be transformed from a petroleum-based industry to a renewable resource-based industry.

The fatty acid synthesis pathways provide a very rich framework for the synthesis of molecules with various chemical structures and carbon chain lengths. In this presentation, the synthesis of various fatty acid like chemicals will be discussed and preliminary data using various metabolically engineered E. coli strains as the production system will be presented.