Monday, July 27, 2009 - 10:00 AM
S150
Achieving Process Intensification with Compact, Single-Use, High Cell Density Bioreactors
Artelis , located in Brussels, Belgium, is developing the iCELLis™ bioreactor technology that achieves process intensification in upstream processing in a multi-factorial approach: 1) single-use components; 2) reduced bioreactor scale; 3) reduced unit operations; and, 4) simplified scale-up. iCELLis bioreactors achieve high cell densities in a fixed-bed operating in perfusion mode. The bioreactor unit is fully disposable thereby eliminating the need for cleaning infrastructure and cleaning validation. The bioreactor design allows compact iCELLis bioreactors to equal the productivity of much larger stirred tank units. Depending on cell type and process, an iCELLis unit can achieve 20-100x the volumetric productivity of a conventional stirred tank bioreactor thereby reducing facility requirements. The biomass multiplication factor within the bioreactor is high so that preculture steps are reduced. Lastly, iCELLis bioreactors are proportional so that processes developed at small-scale can be readily scaled. The effect of the design and operation of the iCELLis bioreactor on upstream process intensification will be presented.
Web Page: www.artelis.be
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