Thursday, July 30, 2009 - 11:00 AM
S132
Rapid Development of Practical Biocatalytic Processes for Pharmaceutical Manufacture
The application of biocatalysis in pharmaceutical development continues to grow as it moves from the domain of specialized technology to mainstream methodology. This move has been facilitated by increasing availability of enzymes at large scale and the recognition that biocatalysis provides environmentally improved processes that result in higher yields and purity, reduce solvent use, and waste, and operate at milder conditions.
This presentation, through actual case studies, will illustrate the development and application of enzyme catalysis from lab-scale through manufacture, with emphasis on the essential performance criteria for ‘industrial readiness’, including biocatalyst availability and productivity, ease of processing, selectivity, yield and volume efficiency. Examples of the scale-up of oxidoreductase processes for the rapid synthesis of chiral intermediates at ALMAC Sciences will be presented. In addition, biocatalysis is finding increasing utility in non-traditional applications, including product purification. Case studies illustrating the purification of difficult to purify complex products using biocatalysis will also be presented.
This presentation, through actual case studies, will illustrate the development and application of enzyme catalysis from lab-scale through manufacture, with emphasis on the essential performance criteria for ‘industrial readiness’, including biocatalyst availability and productivity, ease of processing, selectivity, yield and volume efficiency. Examples of the scale-up of oxidoreductase processes for the rapid synthesis of chiral intermediates at ALMAC Sciences will be presented. In addition, biocatalysis is finding increasing utility in non-traditional applications, including product purification. Case studies illustrating the purification of difficult to purify complex products using biocatalysis will also be presented.
Web Page: www.almacgroup.com
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See more of Industrial case studies for biocatalyst applications
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See more of The Annual Meeting and Exhibition 2009 (July 26 - 30, 2009)
See more of Invited Oral Papers
See more of The Annual Meeting and Exhibition 2009 (July 26 - 30, 2009)