Sunday, July 26, 2009
P67
Antibiotic resistance in Klebsiella pneumonia isolates from urinary infections
Mansoor Rastegar, Fereshte Eftekhar, Masoud Golalipoor, and Nader Mansoorsamaei. Shahid Beheshti University, G. C., Faculty of Biological Science, Daneshjo BLV, Tehran, Iran
Klebsiella sp. is the second cause of urinary tract infections (UTI) after E.coli. Increasing resistance to beta-lactam drugs due to production of extended spectrum beta-lactamases has complicated the treatment of these infections.
We studied the antibiotic resistance patterns of UTI Klebsiella isolates from two hospitals inTehran and determined the minimum inhibitory concentrations (MIC)for beta-lactam antibiotics.
Marerial and methods:
Fifty klebsiella pneumoniae isolates from UTI were identified. Susceptibility to 10 antibiotics was determined by disc diffusion and MIC was determined to the test beta-lactam antibiotics.
Results:
The antibiogram results showed that 96% were resistant to amoxycillin, 80% to nitrofurantoin, 52% to amikacin, 46% to ceftazidime, 40% to ceftriaxone, 38% to cefotaxime, 36% to ceftizoxime, 32% to ciprofloxacin, 30% to imipenem and 28% to gentamicin. MIC results mostly confirmed the antibiogram findings for beta-lavtam antibiotics.
Conclusions:
Detection and control of multi-resistantclinical isolates of bacteria could prevent its endemic dissemination as well as the exposure of critically and susceptible patients to infections.
Keywords: Antibiotic resistance in Klebsiella pneumonia
We studied the antibiotic resistance patterns of UTI Klebsiella isolates from two hospitals in
Marerial and methods:
Fifty klebsiella pneumoniae isolates from UTI were identified. Susceptibility to 10 antibiotics was determined by disc diffusion and MIC was determined to the test beta-lactam antibiotics.
Results:
The antibiogram results showed that 96% were resistant to amoxycillin, 80% to nitrofurantoin, 52% to amikacin, 46% to ceftazidime, 40% to ceftriaxone, 38% to cefotaxime, 36% to ceftizoxime, 32% to ciprofloxacin, 30% to imipenem and 28% to gentamicin. MIC results mostly confirmed the antibiogram findings for beta-lavtam antibiotics.
Conclusions:
Detection and control of multi-resistantclinical isolates of bacteria could prevent its endemic dissemination as well as the exposure of critically and susceptible patients to infections.
Keywords: Antibiotic resistance in Klebsiella pneumonia
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