Tuesday, July 28, 2009 - 11:00 AM
S57
Reduction in analogue generation during Actinomycetes fermentation
Sanjay Tiwari, Bimal Kumar, Naveen Gowda, and Saurabh Garg. Research & Development, Biocon Limited, 20th KM Hosur Main Road, Hebbagodi, Electronic City P.O, Bangalore, India
A wide variety of secondary metabolites like antibiotics, immuno -suppressants, statins etc. are produced by actinomycetes fermentation processes. Though these processes are designed to produce the product of interest, purity at the end of fermentation is invariably less due to formation of various analogues. Typically the similar metabolic pathways that lead to formation of analogues are greatly influenced by some physical as well as chemical process parameters. However, the control of concentration of a key ingredient is often the most powerful tool employed in achieving the desired purity of the main product. This has enabled a reduction in impurity percentage from as high as 5 – 10% to well below 2 % in one case where as a noticeable drop from about 3% to below 1 % in two other cases. This not only makes it easier to achieve ICH grade quality of the product but also reduced the costs. In addition this improves the overall consistency and robustness of production thereby improving plant performance. In this work, the impact of above strategy has been highlighted in several cases.
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See more of Invited Oral Papers
See more of The Annual Meeting and Exhibition 2009 (July 26 - 30, 2009)