Alex Tao, BioVerdant, Inc., 7330 Carroll Road, San Diego, CA 92121
While traditional chemical technologies are extremely powerful in construction of a target molecule via enthalpy-driven covalent bonding, they are much less efficient than the Chemistry of Life in creating structural diversity by entropy-driven non-covalent bonding. Enzymatic catalysis is becoming a transformational technology for green chemistry and chemical manufacture as a result of recent advances in large scale DNA sequencing, structural biology, protein expression, high throughput screening, directed enzyme evolution and pathway engineering. In this presentation, some recent applications of biocatalysis will be described to illustrate an integrated approach to developing efficient green chemistry processes for the production of active pharmaceutical ingredients (Figure 1).