Monday, August 11, 2008 - 9:00 AM
S8
Asymmetric Bioreduction of Ketones in the Pharmaceutical Industry
Carlos Martinez, Chemical R & D, Pfizer Global Research & Development, MS 4073, Eastern Point Road, Groton, CT 06340, CT 06340
Chiral alcohols are important precursors for the synthesis of many pharmaceuticals. Their production by asymmetric bioreduction of ketones represents a powerful alternative competitive to the use of other chemical reduction methods. Herein, selected examples are discussed to highlight the versatile nature of ketone reductases as well as their scalability. The relevance of using ketone reductase in late stage development as well as the common technical challenges will also be discussed. Emphasis will be made on presenting the current state of the art and the green chemistry relevance of this technology.
See more of Industrial Case Studies for Biocatalyst Applications in Pharma
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See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)
See more of Invited Oral Papers
See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)