Monday, August 11, 2008 - 8:00 AM
S23
Metabolic engineering of E. coli for 1,2-propanediol production
François Voelker1, Isabelle Meynial-Salles2, and Philippe Soucaille1. (1) Metabolic Explorer, Biopole Clermont-Limagne, St. Beauzire, 63360, France, (2) Laboratoire d'Ingéniérie des Systèmes Biologiques et des Procédés, INSA, 135, avenue de Rangueil, Toulouse cedex 4, 31077, France
1,2-propanediol or propylene glycol is a bulk chemical, with a huge market, which is currently exclusively produced from a chemical process using propylene as a raw material. As an alternative to this chemical process dependent on fossil carbon, we have developed a biological process for the continuous conversion of glucose to 1,2-propanediol and an oxidized co-product at very high carbon yield and very low production of carbon dioxide. For this purpose, we engineered Escherichia coli by a rational metabolic approach and combined it to our MetEvolTM technology for in vivo evolution.
We will present both the genetic targets of the evolution in the evolved strains and the performances of the further optimized bioprocess to produce 1,2-propanediol at high yield, titer and productivity.
We will present both the genetic targets of the evolution in the evolved strains and the performances of the further optimized bioprocess to produce 1,2-propanediol at high yield, titer and productivity.
See more of Strain improvement and metaboic engineering for chemicals and fuels
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See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)
See more of Invited Oral Papers
See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)