Wednesday, August 13, 2008 - 9:30 AM
S113
Scale-up considerations: Transport phenomena
Sundeep Vani, 038, Archer Daniels Midland, 1001, N. Brush College Road, Decatur, IL 62521
Interest in very large scale fermentations is increasing as industrial biotechnology is gaining greater commercial success and the types of products that can be produced is constantly expanding. Polylactic acid, propanediol and PHA are examples of biobased chemicals which have been recently commercialized or are in the pipeline. Ability to scaleup the fermentation process efficiently and run the plant at optimal performance levels is very important for commercial success. Heat, mass and momentum transfer related problems need to be overcome to successfully accomplish these goals. This paper will take a case study approach to highlight some specific technical problems in each of these areas. For example, the process development and equipment design decisions are different with respect to heat transfer when considering a high metabolic heat load fermentation compared to a fermentation where the metabolic heat load is lower but the optimal operating temperature is lower. Implications of such design and/or operating decisions on actual performance and on specific metabolic responses will be discussed.
See more of Challenges and Solutions in Large Scale Industrial Fermentation
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See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)
See more of Invited Oral Papers
See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)