Tuesday, August 12, 2008 - 11:00 AM
S70

Mass spectrometric approaches to detect natural products from marine cyanobacteria and sponges

Pieter C. Dorrestein1, William Gerwick2, David Gonzalez1, Luke Simmons1, Cameron Coates1, and Eduardo Esquenazi1. (1) Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, Biomedical Sciences Building, Room 4090 9500 Gilman Drive, MC 0636, La Jolla, CA 92093, (2) Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, MC 0212, La Jolla, CA 92093

Marine cyanobacteria and sponges are prolific sources of natural products with therapeutic applications. We will introduce natural product MALDI imaging as well as single cell mass spectrometry based approaches to characterize and observe the spatial distribution of natural products from intact organisms of differing complexities. We analyzed a number of metabolites from the marine cyanobacteria Lyngbya majuscula, Oscillatoria nigro-viridis, Lyngbya bouillonii, even when they were present as mixtures or in sponges. Finally, we outline how these approaches, when combined with single cell genome amplification, can be used to identify specific producers of natural products.

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