Sunday, August 10, 2008
P3
Enzymes for the removal of protecting group - Enzymatic hydrolysis of t-butyl ester
In multi-step synthesis, one option for protection of carboxylic acids is as a t-butyl ester. Typically a t-butyl ester group is chosen to enable facile cleavage by acid catalyzed hydrolysis. During development of a process for an HMG CoA inhibitor, it was desirable to identify alternative deprotection processes for a t-butyl ester protected intermediate. Our group evaluated enzymes for their utility in this transformation and found several that were effective. The screening results were utilized to develop a laboratory process for enzymatic hydrolysis of the t-butyl ester protecting group.
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