Monday, August 11, 2008 - 11:00 AM
S31
Biosynthesis of enediyne antitumor antibiotic C-1027
Steven G. Van Lanen, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, KY 40536
The enediyne C-1027 is a potent antitumor antibiotic isolated from Streptomyces globisporus. The biosynthesis of C-1027 is hypothesized to conclude with the convergent assembly of four components: a deoxy aminosugar, an enediyne core, a b-amino acid and a benzoxazolinate moiety. Using an in vivo and in vitro approach, the intial enzymatic conversions for each compotent have been identified and characterized to reveal a new branching point in chorismate metabolism, a b-amino acid activing adenylation enzyme, and an iterative type I polyketide synthase.
See more of Biosynthetic enzyme mechanisms and combinatorial biosynthesis
See more of Invited Oral Papers
See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)
See more of Invited Oral Papers
See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)