Tuesday, August 12, 2008 - 3:00 PM
S77
Epigenetic control and native expression of silent secondary metabolic pathways
Robert H. Cichewicz, Department of Chemistry and Biochemistry, Natural Products Discovery Group, University of Oklahoma, 620 Parrington Oval, Rm 208, Norman, OK 73019
Epigenetic mechanisms are widely utilized throughout nature as a means of attenuating the expression of portions of an organism’s genome. Fungi have refined this process for the suppression and exquisite regulation of natural products production. Consequently, traditional fungal culturing methods are not conducive for the expression of many silent biosynthetic pathways thereby limiting opportunities for biomolecule discovery. Using a library of small molecule agents targeting fungal epigenetic processes, we are able to facilitate the native expression of silent secondary metabolic pathways. When tested against a phylogenetically diverse panel of fungi, this method provided a simple and economical means for rapidly procuring new natural products.
See more of Cryptic Pathways and Symbionts-Unveiling Nature's Hidden Pathways
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See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)
See more of Invited Oral Papers
See more of The Annual Meeting and Exhibition 2008 (August 10 - 14, 2008)