Monday, July 30, 2007
P82

Design of a purification process for recombinant human erythropoietin (rHuEPO) produced in vivo by Nicotiana tabacum; engineering, economics, and beyond

Cory D. Jensen1, Shytyug Loh2, Ranil Wickramasinghe2, Ching-lun Hsiao2, and Chen Guo2. (1) Merrick and Company, 2450 South Peoria St., Aurora, CO 80013, (2) Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO 80525

Transgenic plants are emerging as a means of producing biological and pharmaceutical products.  Multiple disciplines face a frontier of creative process development and biotechnology advances with the commercialization of health care products taken from Planta.  We have envisioned one such process that utilizes recombinant human erythropoietin (rHuEPO) produced in vivo by Nicotiana tabacum.  We present one possible process for the recovery of rHuEPO.  This poster highlights some state of the art technology that would make the process of rHuEPO recovery possible.  We also consider aspects such as regulations and economics that need to be evaluated to determine if such a large scale process would be practical.  This theoretical process development for transgenic rHuEPO can be used as a model design strategy for students, researchers, biological engineers, and industrial microbiologists alike.

See more of Poster Session 2
See more of Posters

See more of The Annual Meeting and Exhibition 2007 (July 29 - August 2, 2007)