During the continued screening, we obtained another coastal isolate which produces a novel antifungal metabolite. The producer strain was unique in that it shows low level salt requirement(i.e.maximum growth at 0.5% NaCl), and was phylogenetically affiliated as new genus in myxobacteria.  We also described the fermentation, chemical structures and biological characteristics of the compound, halogenated depsipeptides (miuraenamides).  In addition to the halophiles as mentioned, we also demonstrated the existence of slightly thermophilic myxobacteria which inhabit in various Japanese hot-springs. Based on the 16S rDNA gene analysis, the diverse species of thermophiles inhabit in hot-spring of both marine and terrestrial environments. In summary, these findings have broadened our understanding of the ecological and physiological aspects of the bacteria and, with the improved methods of isolation and cultivation, provide the access to this new promising source for natural products.