Monday, July 30, 2007 - 2:30 PM
S55

Genetic Engineering of Thermoacidophilic Archaea: Postgenomic Bioprocess with Extremophiles

Paul Blum1, Yukari Maezato2, Edith Soo2, Amanda Dougherty2, and Karl Dana2. (1) Beadle Center for Genetics, University of Nebraska, Lincoln, NE 68588-0666, (2) Beadle Center for Genetics, Univeristy of Nebraska - Lincoln, Lincoln, NE 68588-0666

The number of genomic sequences are rapidly increasing for microbial extremophiles including members of the Archaea. Gene mining of this data strongly stimulates research and applications in bioenergy, bioprocess, evolution and ecology. Functional genomic studies using genetics are essential for leveraging this information. The Blum lab has pioneered development of a tractable genetic system for the archaeon Sulfolobus solfataricus. An expanded suite of methodologies and their use in studying basic molecular processes will be presented. Topic will include: gene silencing, small coding RNA function, and polarity. Recent extension of the genetic system to include related crenarchaeota using functional metagenomics promises exciting new opportunities in this field.


Web Page: bsweb.unl.edu/labs/blum/index.html

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