Bio-mineral processing for metal recovery from sulphide ores and concentrates is considered very attractive in view of low energy consumption and environmentally benign option. This work illustrates recovering copper from lean grade copper ore with 0.3% Cu of Malanjkhand Copper Project (MCP). In Malanjkhand Copper mine, lean grade ore with 0.3-0.4% copper, which is adjacent to the rich grade ore is accumulated in tonnage level and can certainly be utilized to meet the growing demand of the country. The conventional processes are not suitable to treat this low grade ore as the desired grade with acceptable yield can not be achieved. Different parameters such as pH, temperature, pulp density, particle size, etc; were optimised in shake flasks using Acidithiobacillus ferrooxidans (Tf) isolated from the source mine water and adapted on ore. Sterile sets were run to assess the contribution of chemical leaching; but recorded very poor metal recoveries. A high redox potential (540 to 661mV) observed during the bioleaching resulted in 75.3% Cu biorecovery at 35^oC for particles of <50μm size in 35 days at 2.0pH and 5%PD with a rise in cell count from 1x10⁷ cells/mL to 1.13x10⁹ cells/mL. Biodissolution of copper appeared to follow direct and indirect mechanism.