Tuesday, July 31, 2007 - 11:00 AM
S74

Strain Development based on Microscale Fermentation

Lei Han, Bioprocess R&D, Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268

Microscale fermentation enjoys increasing popularity because of the many exciting research advantages it affords: high throughput, reduced resource demand, broad variable evaluation, rapid parameter optimization, etc.. We have developed and continue to optimize a microscale fermentation system specifically for screening mutants of the insecticide producer, Saccharopolyspora spinosa. In this presentation, representative issues and solutions related to this microscale fermentation system will be highlighted. The ability of the system in ranking the historical strains, identifying new strains, and predicting strain performance in stirred tanks will be discussed.

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