Wednesday, August 1, 2007 - 10:30 AM
S130

Protein ‘tools' for nano-technology: Sulfolobus' contribution to the next generation of hard drives

Jonathan Trent, Bioengineering Branch, NASA Ames Research Center, Mail Stop 239-15, Moffett Field, CA 94035

As engineering focuses attention on controlling and manipulating nano-scale materials and processes, a role for biomolecules, like proteins, is emerging to address the fundamental problems associated with working at the nanometer-size scale.  Proteins can be readily modified using genetic engineering and induced to interact with a surprising range of organic and inorganic materials.  We are using genetic engineering to modify proteins from extremophiles to bind metals and semi-conducting materials and to direct or redirect the inherent properties of these proteins to self-assemble into useful nanostructures. In particular, I will describe our use of the genetically engineered 60-kDa heat shock proteins (HSP60s) from Sulfolobus shibatae, which naturally self-assemble into robust double-ring structures, called “rosettasomes.” We have manipulated rosettasomes to use them as templates for arranging nanoparticles in arrays with nanometer precision.  I will discuss how these arrays can be used for applications in data storage on computer hard drives.


Web Page: bionanex.arc.nasa.gov