Our research objective is to optimize microwave assisted lime pretreatment of sweet sorghum bagasse for its enzymatic conversion to fermentable sugars. Sweet sorghum biomass was ground and passed through a 40 mesh screen. Moisture content of the biomass was approximately 12%. It had 48% cellulose, 21% hemicelluloses, and 15% acid detergent lignin on dry matter basis. Lime pretreatment was provided in a microwave oven at 1 atmospheric pressure. The lime concentration was 0.05, 0.10 and 0.15 g/g biomass; reaction time in a microwave oven was 10 min, 20 min and 30 min. Liquid loading was varied from 10 to 20 ml water /g biomass sample. Pretreated biomass was hydrolyzed with a commercial enzyme AcceleraseTM 1000, and tested for total reducing sugars and lignin content. A linear trend was observed showing a steady increase in sugar yield and lignin degradation with increased dose of lime and increasing time of microwave treatment. The preliminary data has shown a high potential for lime pretreatment as a cheaper process for production of fermentable sugars from sweet sorghum bagasse.