Monday, July 30, 2007: 8:00 AM-11:45 AM
Centennial H, third level
Session 6: Natural Products: Natural products as anticancer agents: From discovery to development
Conveners:R. Lam
G.T. Carter
8:00 AMUnnatural selection and the evolution of anticancer agent Ixabepilone: Optimizing the fermentation and drug-like properties of epothilones
Gregory D. Vite
8:30 AMAnticancer drug discovery from marine cyanobacteria; new molecules working by new mechanisms
William Gerwick, Wolf Wrasidlo, Kerry McPhail, Eric Andrianasolo
9:00 AMFrom sea bed to sick bed, discovery and development of a novel proteasome inhibitor from a marine actinomycete
R. Lam
9:30 AMBreak
10:15 AMWhat do you do with a natural product that is too toxic
Mark Ruppen, Justin Moran, Jason Lotvin
10:45 AMECO-4601, a Novel Anticancer Pharmacophore. Development through Phase I
James B. McAlpine
11:15 AMPyranonaphthoquinone inhibitors of AKT kinase
Leonard A. McDonald, Laurel R. Barbieri, Ker Yu, Lourdes Toral-Barza, Wei-Guo Zhang, Jason Lotvin, Ping Cai, Gow-Jen Tsai, Xidong Feng, Edward J. Salaski, Wei-Dong Ding, Girija Krishnamurthy, Guy T. Carter

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